Kim Annink

60 Chapter 3 The postnatal age at death was not significantly different between the different HLA-DR and CD68 categories, except for the CD68 staining in the DN (p=0.024) in which the patients with score 0 died at a median of 5 days after birth and the infants with score 3 at a median of 3 days after birth. ADC values versus histopathology The ADC values in the vermis were significantly correlated with the amount of normal PC per 1000 µm and the percentage of normal PCs in the vermis. In the cerebellar hemispheres and DN there was no correlation between the ADC and the neuron/PC measures (Figure 4A,C,E). ADC values in the cerebellar hemispheres, vermis and DN did not differ between no, mild, moderate and severe CD68 stained slices of these structures (Figure 4B,D,F). The same applied to HLA-DR staining. The patients with low ADC values in the hemispheres did have severe CD68 staining of the hemisphere and the patient with low ADC values in DN did have severe CD68 and HLA-DR staining of the DN (Figure 4D,E). The median ADC values in the vermis were not significantly different between infants with no, mild, moderate and severe histopathological cytotoxic edema of the vermis (p=0.08). The mean ADC values in the cerebellar hemispheres were also not significantly different between infants with no, mild, moderate and severe histopathological cytotoxic edema of the hemispheres (p=0.36). The ADC values in the DN were comparable between the cytotoxic edema categories in the DN (p=0.70). See Figure 5.