Kim Annink

TABLE OF CONTENTS Chapter 1 General introduction p. 8 Part I: neuroimaging and follow-up Chapter 2 Uneven distribution of Purkinje cell injury in the cerebellar vermis of term neonates with hypoxic-ischemic encephalopathy p. 30 Chapter 3 Cerebellar injury in term neonates with hypoxic-ischemic encephalopathy is underestimated with antemortem diffusion weighted MRI in comparison to postmortem histopathology p. 48 Chapter 4 The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischemic encephalopathy p. 70 Chapter 5 The long-term effect of perinatal asphyxia on hippocampal volumes p. 92 Chapter 6 The Papez Circuit and school-age outcome following neonatal hypoxic- ischemic encephalopathy p. 112 Part II: neuroprotection Chapter 7 Allopurinol: Old Drug, New Indication in Neonates? p. 146 Chapter 8 Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III) p. 172 Chapter 9 Pharmacokinetic evaluation of the allopurinol dosing regimen in term infants with perinatal asphyxia in the ALBINO trial p. 192 Part III: innovative neuroimaging techniques Chapter 10 Brain temperature of infants with neonatal encephalopathy following perinatal asphyxia calculated using magnetic resonance spectroscopy p. 216 Chapter 11 Introduction of ultra-high field magnetic resonance imaging in infants: preparations and feasibility p. 234 Chapter 12 General discussion Conclusions & clinical implications Future directions p. 252 Chapter 13 Nederlandse samenvatting (summary in Dutch) p. 276 Chapter 14 List of abbreviations List of coauthors List of publications Curriculum vitae Dankwoord (Acknowledgments) p. 290