Kim Annink

82 Chapter 4 Figure 2: Cerebral ultrasound, outcome and HIE: subscores. Grey matter subscores (A) and white matter subscores (B) of cohort I on day one and day three to seven, categorized for outcome. The cumulative score of the white matter (OR=2.6, 95%CI 1.5-4.7) and of the deep grey matter involvement (OR=2.7, 95%CI 1.7-4.4) between day three and seven after birth were included in the final scoring system. The RI was not significant in multivariable logistic regression. The probability of an adverse outcome at the age of two years could be calculated using the following formula: 1/(1+e -(-3.385+0.960*white matter+0.995*deep grey matter) ). The CUS scoring system performed well in cohort I (area under the curve (AUC)=0.90; 95%CI 0.83-0.98). Table 4 shows the performance per cut-off value.