Kim Annink

Chapter 1 General introduction	8
Chapter 2 Uneven distribution of Purkinje cell injury in the cerebellar vermis of term neonates with hypoxic-ischemic encephalopathy	30
Chapter 3 Cerebellar injury in term neonates with hypoxic-ischemic encephalopathy is underestimated with antemortem diffusion weighted MRI in comparison to postmortem histopathology	48
Chapter 4 The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischemic encephalopathy	70
Chapter 5 The long-term effect of perinatal asphyxia on hippocampal volumes	92
Chapter 6 The Papez Circuit and school-age outcome following neonatal hypoxicischemic encephalopathy	112
Chapter 7 Allopurinol: Old Drug, New Indication in Neonates?	146
Chapter 8 Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)	172
Chapter 9 Pharmacokinetic evaluation of the allopurinol dosing regimen in term infants with perinatal asphyxia in the ALBINO trial	192
Chapter 10 Brain temperature of infants with neonatal encephalopathy following perinatal asphyxia calculated using magnetic resonance spectroscopy	216
Chapter 11 Introduction of ultra-high field magnetic resonance imaging in infants: preparations and feasibility	234
General discussion	254
Conclusions & clinical implications	264
Future directions	265
Nederlandse samenvatting (summary in Dutch)	278
List of abbreviations	292
List of coauthors	295
List of publications	303
Curriculum vitae	305
Dankwoord (Acknowledgments)	306

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