Caren van Roekel

103 Quality of life in patients treated with 166 Ho-radioembolization populations, such as older patients or patients with multiple comorbidities, QoL is largely maintained. This can be a reason to prefer RE over other treatment modalities (28). Furthermore, since RE is becoming more important in the first- and second-line settings, the impact of this therapy on QoL is also becoming more significant. CONCLUSION In conclusion, QoL in salvage patients with liver metastases treated with 166 Ho- RE was not significantly affected over time, apart from a decline during the first week after treatment. Changes in QoL were most notable during the first week post-treatment, probably due to the post-embolization syndrome. A WHO performance score >0 at baseline significantly influenced QoL. Knowledge of the influence on quality of life of 166 Ho-RE is important for patients to make a deliberate choice between palliative treatment options. LIST OF ABBREVIATIONS 90 Y  yttrium-90 99m Tc-MAA  technetium 99m Tc macro-aggregated albumin 166 Ho  holmium-166 AP  appetite loss CF  cognitive functioning CO  constipation DI  diarrhoea DY  dyspnoea EF  emotional functioning EORTC  European Organization for Research and Treatment of Cancer FA  fatigue FI  financial difficulties GHS  global health status HCC  hepatocellular carcinoma LMCDM  dry mouth LMCEp  emotional problems LMCFati  fatigue 3