Caren van Roekel

128 Chapter 4 Treatment characteristics Coil-embolization of non-target vessels was performed in 62 patients. The median duration of the simulation angiography with administration of 166 Ho- scout was 1:43 hours (range 0:31-4:40 hours). Patients had a median wait time of 31 minutes (range 0:10-2:45 hours) before imaging with 166 Ho-SPECT/CT was performed. After SPECT/CT imaging, median wait time was 2:28 hours (range 0:17-4:30 hours). The median duration of the treatment procedure was 1:11 hours (range 0:12-2:42 hours). The median total procedure time (i.e. simulation, imaging and treatment) was 6:39 hours (range 3:58-9:17 hours). Extrahepatic deposition on SPECT/CT after treatment was seen in five patients (falciform ligament (n=3), the hepatoduodenal ligament (n=1) and a portocaval lymph node (n=1)), but did not have any clinical consequences during follow- up. Safety Overall, the one-day treatment procedure was well tolerated. After administration of 166 Ho-scout patients experienced back pain (19%), abdominal pain (5%), allergic contrast reaction (3%), nausea (1%), vomiting (1%), and dyspnea (1%). After administration of the therapeutic activity, patients experienced abdominal pain (51%), nausea (45%), vomiting (27%), back pain (27%), and chest pain (1%) (Table 2). Additional analgesics were administered in 30 patients during or after treatment (specifically for back pain in 17 patients). The indwelling arterial sheath, that remained in situ for a median duration of 6:39h, did not cause any adverse events. After removal, a minor bleeding occurred in three patients, which resolved with manual compression.