Caren van Roekel

129 One-day treatment in 166 Ho-radioembolization TABLE 2. CTCAE grading of reported adverse events during same-day treatment with 166 Ho- radioembolization Adverse event CTCAE grade I CTCAE grade II CTCAE grade III Adverse events between simulation procedure and treatment procedure Back pain N=13 N=6 N=1 Abdominal pain N=4 N=1 Allergic reaction N=3 Nausea N=1 Vomiting N=1 Dyspnea N=1 Adverse events after treatment procedure on the treatment day Abdominal pain N=14 N=26 N=12 Nausea N=13 N=29 N=5 Vomiting N=6 N=19 N=3 Back pain N=14 N=11 N=3 Chest pain N=1 DISCUSSION As shown in this study, same-day simulation and treatment in 166 Ho- radioembolization is feasible in most cases: 105 of 120 scheduled patients were treated. The treatment plan was adjusted in 14 patients based on the findings of the simulation angiography. The clinical adverse events that occurred during the treatment day were similar to the known side-effects of radioembolization, apart from additional back pain, which was likely caused by the long duration of lying in a supine position. Although not part of this study, savings in time and costs can be potential advantages of a one-day treatment protocol (5). Especially patients who have to travel a long distance or have progressive disease can benefit from a timely treatment. In addition, leaving a vascular sheath in the groin between the two angiographies avoids repeated groin punctures. However, a 12% cancellation rate and an additional 12% modification rate, as found in this study, may hamper cost-effectiveness. The 166 Ho-activity 4