Caren van Roekel

148 Chapter 5 Correlations between baseline characteristics and response The association between several baseline characteristics and response was assessed (Table 2). Presence of extrahepatic disease was the most significant risk factor for progressive disease, with an OR of 7.8 (95% CI 2.37-35.53) for patients with extrahepatic disease at baseline versus patients without extrahepatic disease at baseline (Figure 3). Extrahepatic metastases at baseline increased the risk of progressive disease for all modes of progression, mainly for new extrahepatic metastases (OR=3.06, 95% CI 1.28-7.72). Time since diagnosis of metastases was a significant risk factor for progressive disease as well, with an OR of 1.06 for every month increase in time (95%CI 1.01-1.11). Primary tumor location showed a strong trend, with an OR of 3.88 (95%CI 1.00-25.75) for patients with right-sided primary tumors versus patients with left-sided primary tumors. There was no significant difference between type of microspheres used. FIGURE 3. Forest plot of the influence of baseline characteristics on response (progression versus no progression according to RECIST 1.1), based on univariable analyses.