Caren van Roekel

151 Mode of progression after radioembolization in colorectal cancer patients FIGURE 4. Kaplan-Meier survival curve stratified for extrahepatic metastases at baseline. DISCUSSION This study shows that a large proportion of end-stage mCRC patients have progressive disease after radioembolization due to the development of new metastases, and to a lesser extent on the growth of existing metastases. The presence of extrahepatic disease at baseline significantly increases the chance of early progressive disease at three months, especially the development of new metastases. Moreover, patients with extrahepatic metastases at baseline had a significantly worse overall survival. At baseline, 48% of our study population was diagnosed with extrahepatic metastases. This is in line with other studies in which 35-77% of the included patients had extrahepatic metastases at baseline (18-20, 39-44). We found a difference in median OS with- and without the presence of extrahepatic metastases at baseline, respectively 7 versus 10 months (p=0.0018). Several 5