Caren van Roekel

171 Dose-response relationship in 166 Ho-radioembolization Local Response In total, 98 tumors were delineated. The median number of tumors per patient was 2 (range 1-9). Median tumor absorbed dose was 162.1 Gy (range 16.4 – 715.7 Gy). Median absorbed dose in the healthy liver tissue was 39.9 Gy (range 7.2 – 66.4 Gy). Metabolic tumor response at three months follow-up was: CR in 32 tumors, PR in 17 tumors, STBD in 28 tumors and PD in 21 tumors. The local metabolic response versus absorbed dose is plotted graphically in Figure 1. FIGURE 1. Graphical representation of the metabolic response (i.e. change in total lesion glycolysis (TLG)) versus absorbed dose of each individual tumor. A decrease in TLG is associated with a higher tumor absorbed dose. Vertical dashed line indicates the cut-off value for TLG change, below which a complete (CR) or partial (PR) response was observed, and above which response is defined as either stable (STBD) or progressive (PD) disease. Shaded area indicates 95% CI of the regression line. Geometric mean tumor absorbed doses in the response categories at a tumor level were as follows: CR 232 Gy (95%-confidence interval (CI): 178-303 Gy), PR 6