Caren van Roekel

193 Dose-effect relationships of holmium-166 radioembolization in colorectal cancer FIGURE 2A-F. Association between change in laboratory parameters and parenchymal absorbed dose. The red lines are the regression lines, with the 95%CIs indicated as the surrounding grey areas. Efficacy Solely based on the metabolic response of measurable hepatic metastases at baseline, there was one patient with CR, PR was reached in 11 patients, 17 patients had StD and PD was found in eight patients at three-months follow-up. On a lesion level, CR occurred in 23 lesions, PR in 20 lesions, StD in 49 lesions and 23 lesions were progressive. A significant dose-response relation was found on patient- and tumor-level. The mean tumor-absorbed dose was 77% higher in patients with CR/PR than in patients with PD (95%CI: 18-164%, p=0.011) and the mean absorbed dose was 95% higher in lesions with CR than in lesions with PD (34-188%, p=0.00065) (Table 3). Mean absorbed doses per response category are visualized in Figure 3. 7