Caren van Roekel

205 Dose-effect relationships of holmium-166 radioembolization in colorectal cancer SUPPLEMENTAL TABLES TABLE S1. Relation between parenchymal dose (Gy) and clinical toxicity based on linear regression analyses with parenchymal dose as the dependent variable Independent variable Number of patients with toxicity CTCAE grade 0 -V Mean change in parenchymal dose (Gy) per step increase in CTCAE grade category (95% CI); p-value Unadjusted Adjusted (for tumor dose, previous treatment and response) Any variable, highest grade 40 3.43 (-0.23 – 7.10); 0.065 6.56 (1.96 – 11.16); 0.0067 Abdominal pain 30 0.26 (-3.24 – 3.77); 0.88 0.99 (-3.06 – 5.04); 0.62 Nausea 26 3.09 (-0.46 – 6.65); 0.086 2.62 (-0.99 – 6.22); 0.15 Vomiting 14 1.70 (-2.87 – 6.26); 0.46 2.33 (-2.27 – 6.93); 0.31 Fatigue 33 3.78 (-0.25 – 7.81); 0.065 3.66 (-0.60 – 7.91); 0.090 Fever 9 3.61 (-1.32 – 8.55); 0.15 4.85 (-2.44 – 12.13); 0.18 Anorexia 15 1.13 (-3.46 – 5.71); 0.62 0.47 (-4.42 – 5.37); 0.85 Ascites 3 2.92 (-1.86 – 7.70); 0.22 6.86 (0.53 – 13.19); 0.035 The mean change indicates the average increase or decrease in parenchymal dose per step increase in CTCAE grade toxicity. For example, for any clinical toxicity: a unit increase in toxicity results in an increase in average parenchymal dose of 3.4 Gy (unadjusted analysis). TABLE S2. Relation between parenchymal dose (Gy) and cumulative toxicity over three months, based on logistic regression analyses using Firth’s correction with parenchymal dose (per 10 Gy) as the independent variable Dependent variable CTCAE grade 0-II vs III-V Odds ratio for toxicity parameter per 10 Gy increase in parenchymal dose (95% CI); p-value Unadjusted model Adjusted model (for tumor dose, previous treatment and response) Any variable laboratory toxicity, highest grade (n=33 vs n=7) 1.05 (0.46 – 2.48); 0.91 1.08 (0.39 – 3.12); 0.88 Any variable clinical toxicity, highest grade (n=32 vs n=8) 3.61 (1.37 – 13.10); 0.022 9.68 (2.18 – 124.20); 0.019 The odds ratio represents the odds for a CTCAE grade III-V toxicity for every 10 Gy increase in parenchymal absorbed dose. 7