Caren van Roekel

242 Chapter 9 FIGURE 4A-D. Intention-to-treat analyses of effect of anti-reflux catheter on T/N activity concentration ratio (a), mean tumor-absorbed dose (b), mean parenchymal-absorbed dose (c) and infusion efficiency (d). The per-protocol analyses were performed in 17 patients. Median T/N activity concentration ratio with the antireflux catheter was 3.2 (range 0.9-8.7); with the standard microcatheter 3.6 (range 0.8-13.3) (p=0.82, 95%CI -1.19 - 1.24). Median tumor-absorbed dose was 129 Gy (range 55-302) with the anti-reflux catheter versus 107 Gy (range 17-363) with the standard microcatheter (p=0.61, 95%CI -33 - 49). Median parenchymal-absorbed dose was 38 Gy (range 15-67) with the anti-reflux catheter and 30 Gy (range 20-57) with the standard microcatheter (p=0.13, 95%CI -3-14). Infusion efficiency with the anti-reflux catheter was