Caren van Roekel

TABLE OF CONTENTS Chapter 1 Introduction and outline 7 Chapter 2 Radioembolization 15 Chapter 3 Quality of life in patients with liver tumors treated with holmium-166 radioembolization 87 Chapter 4 Evaluation of the safety and feasibility of same day 166 Ho-radioembolization simulation and treatment of hepatic metastases 119 Chapter 5 Mode of progression after radioembolization in patients with colorectal cancer liver metastases 135 Chapter 6 First evidence for a dose-response relationship in patients treated with 166 Ho-radioembolization: a prospective study 163 Chapter 7 Dose-effect relationships of holmium-166 radioembolization in colorectal cancer 181 Chapter 8 The efficacy of coil-embolization to obtain intrahepatic redistribution in radioembolization: qualitative and quantitative analyses 209 Chapter 9 Use of an anti-reflux catheter to improve tumor targeting for holmium-166 radioembolization – a prospective, within-patient randomized study 229 Chapter 10 Discussion 257 Chapter 11 Summary 291 Chapter 12 Nederlandse samenvatting 305 Chapter 13 Addenda 319 Review Committee 321 List of publications 322 Dankwoord 324 Biography 328