Caren van Roekel

95 Quality of life in patients treated with 166 Ho-radioembolization Descriptive analyses were performed to summarize patient demographics and treatment characteristics. A linear mixed-effects regression model was fitted to evaluate the development of QoL, taking into account all available data (35). The influence of the following variables on QoL was tested, as these were believed to be of possible influence on QoL: gender (male versus female), previous treatments (systemic, locoregional, both or none), extrahepatic disease at baseline (yes/no), performance status at baseline (WHO score 0, 1 or 2), primary tumor type (colorectal carcinoma versus other), time and response category (complete response, partial response, stable disease or progressive disease). Random effects were tested based on Akaike’s information criterion and fixed effects were tested using a backward stepwise approach. A relatively conservative P-value ≤0.001 (instead of ≤0.05) was considered statistically significant in order to reduce type I errors (36). Statistical analyses were performed using R (version 3.5.1). RESULTS QoL was studied in a total of 53 patients treated with 166 Ho-RE between November 2009 and March 2015; 15 patients in the HEPAR I study and 38 patients in the HEPAR II study (Flowchart for study inclusions: Figure S2). Patient characteristics are listed in Table 2. TABLE 2. Baseline characteristics of treated patients in the HEPAR I and II studies Characteristic Value N 53 Age (years) Median (range) 66 (38-87) Gender Male, % 31 (58%) Primary tumour – no. Colorectal carcinoma 29 Ocular melanoma 8 Cholangiocarcinoma 6 Breast carcinoma 5 3