Koos Boeve

105 Cyclin D1 in early oral cancer Table 1. Baseline characteristics of initial and validation cohorts Initial (158 tumors) Validation (155 tumors) Center UMC Utrecht 158 (100%) 73 (47%) UMC Groningen 0 (0%) 82 (53%) Age (mean, range in years) 62, 23-90 62, 25-94 Sex male 97 (61%) 87 (56%) female 61 (39%) 68 (44%) Smoking no 75 (47%) NA yes 83 (53%) Alcohol no 76 (48%) NA yes 82 (52%) Location FOM 65 (41%) 68 (44%) tongue 93 (59%) 87 (56%) Clinical T-classification T1 77 (49%) 51 (33%) T2 81 (51%) 104 (67%) Treatment Surgery 122 (77%) 89 (57%) Surgery + PO(Ch)RT 36 (23%) 66 (43%) Neck dissection No* 41 (26%) 0 (0%) yes 117 (74%) 155 (100%) Infiltration depth 0-4 mm 54 (34%) NA >4 mm 104 (66%) Perineural growth no 115 (73%) NA yes 43 (27%) Vascular invasive growth no 144 (91%) NA yes 14 (9%)