Koos Boeve

110 Chapter 6 Figure 1. Immunohistochemical staining of cyclin D1 (% of nuclear staining), FADD (intensity of cytoplasmic staining) and cortactin (intensity of cytoplasmic staining) on oral cancer and normal oral mucosa (first column). Separate analysis per subsite, showed that in early FOM oral cavity SCC the most significant biomarkers ( CCND1 amplification and cyclin D1 overexpression) have a higher NPV of 95% (p = 0.021) for cyclin D1 normal expression and 97% (p = 0.067) for CCND1 normal copy number by FISH, compared with a NPV of 76% for both techniques in early tongue oral cavity SCC. Although CCND1 normal copy number FOM OSCC shows the highest NPV, the correlation is not significant (see Table 4).