Koos Boeve

127 Molecular biomarkers in SLNB staged early oral cancer Table 1. Patient and tumor characteristics and true N-status True N negative True N positive p-value n (%) n (%) Total 57 (66) 30 (34) Gender male 30 (53) 12 (40) 0.367 female 27 (47) 18 (60) Age at first treatment median (IQR) 64 (57 to 71) 66 (59 to 75) 0.302 Site tongue 31 (54) 21 (70) 0.209 floor of mouth 19 (33) 4 (13) cheek 3 (5) 4 (13) others 4 (7) 1 (3) pT status (7 th TNM) 1 50 (88) 19 (63) 0.012 2 7 (12) 11 (37) Tumor infiltration depth (mm) median (IQR) 3.5 (2.0 to 5.0) 5.0 (3.6 to 7.0) 0.007 Tumor infiltration depth <4.0 mm 31 (54) 9 (30) 0.042 ≥4.0 mm 26 (46) 21 (70) Perineural invasion no 55 (97) 24 (80) 0.018 yes 2 (3) 6 (20) Lymphovascular invasion no 53 (93) 25 (83) 0.265 Yes 4 (7) 5 (17) Tumor grade well 19 (33) 6 (20) 0.222 moderate 38 (67) 24 (80) Tumor pattern of invasion pushing 42 (64) 11 (37) 0.001 infiltrative 15 (25) 19 (60) Cortactin low expression 43 (75) 18 (60) 0.148