Koos Boeve

163 Methylation biomarkers for the detection of tumor DNA in saliva Supplementary data 1. Continued Gene name Chromosome locus Gene regio start (GSE42409) Gene regio end (GSE42409) p-value (Mann- W hitney U test) Number of reads O SCC patient 1 O SCC patient 2 O SCC patient 3 O SCC patient 4 O SCC patient 5 O SCC patient 6 O SCC patient 7 O SCC patient 8 O SCC patient 9 O SCC patient 10 O SCC patient 11 O SCC patient 12 Leukocyte pool 1 Leukocyte pool 2 TMEM18 2 678865 678866 0 .007 1 0 0 1 1 0 0 1 0 1 1 0 0 0 ZFAND6 15 80350338 80350339 0 .007 0 1 1 0 0 1 0 1 0 0 1 1 1 1 U6 1 22314468 22314516 0 .007 0 1 0 1 0 0 1 0 1 1 1 0 1 1 SPI1 11 47400930 47401026 0 .007 1 0 0 1 0 1 0 0 1 0 1 1 1 1 SLC15A3 11 60720092 60720229 0 .007 0 0 0 1 1 0 1 1 0 0 1 1 1 1 AP000770.1 11 116510340 116510341 0 .007 1 0 0 1 1 0 0 1 1 0 0 1 1 1 SCARNA11 12 8748456 8748579 0 .007 1 1 0 1 0 0 0 0 1 0 1 1 1 1 COMP 19 18903207 18903230 0 .007 0 0 1 1 0 0 1 1 0 0 1 1 1 1 INSM1 20 20348794 20348956 0 .007 0 0 1 1 1 0 1 1 0 0 1 0 1 1 C16orf81 16 89226057 89226378 0 .007 7 12 6 12 8 15 9 11 10 5 15 9 13 14 AC012652.1 15 41521764 41522036 0 .007 8 8 2 9 11 5 7 10 5 7 11 7 10 10 CNIH 14 54910018 54910240 0 .007 7 13 7 10 3 6 11 13 12 7 15 4 15 17 SPO11 20 55904448 55905206 0.008 6 16 8 9 8 18 7 15 6 11 14 6 18 16 AC018755.9 19 52101660 52102180 0.008 6 15 8 11 11 6 11 22 8 12 14 8 16 15 AC008271.1 2 15830701 15831610 0.008 10 8 7 9 7 13 17 13 11 14 14 9 8 8 TACR2 10 71175640 71176127 0.008 8 8 7 5 6 12 17 12 9 8 8 7 12 13 5S_rRNA 1 228770930 228771604 0.008 14 29 7 6 2 8 32 30 7 16 23 17 31 27 CDKN3 14 54861108 54861777 0.008 8 9 7 5 8 9 10 12 14 6 9 5 11 11 AL356957.13 1 149287899 149288411 0.008 8 9 6 7 4 5 10 9 7 3 15 3 4 4 AC118470.1 1 247802955 247803176 0.009 12 7 5 4 4 7 20 7 6 6 5 2 3 2 AL139161.2 1 236136540 236137128 0.009 6 6 7 5 6 6 9 7 8 7 9 5 8 8 TMEM85 15 34515638 34515959 0.009 3 10 6 7 7 6 7 7 7 9 11 7 10 11 MRPL28 16 422537 423002 0.009 9 10 5 5 9 6 8 11 19 6 10 5 13 12 Y_RNA 14 100048449 100049145 0.009 6 14 6 13 8 5 14 13 15 8 7 8 13 14 AL928742.3 14 106004966 106005349 0.010 5 10 7 7 6 13 4 10 16 9 21 5 14 14 CALML5 10 5540692 5541293 0.010 4 15 7 8 8 4 9 15 4 8 16 11 13 13 INHA 2 220431911 220432323 0.010 8 8 4 12 6 10 11 9 11 5 17 4 13 12 GPS1 17 80008024 80008393 0.010 5 10 7 13 9 7 15 13 14 8 13 6 13 14 AC011491.1 19 6378815 6379216 0.011 9 14 7 6 6 5 13 11 7 6 10 4 12 11 AC104841.1 2 242165415 242165901 0.011 7 12 8 8 8 6 14 13 12 8 8 8 7 7 AL391244.1 1 1354451 1355097 0.011 10 14 11 13 8 12 8 17 14 11 18 6 15 15 ESPNP 1 17046419 17046814 0.011 8 15 10 7 6 7 11 10 8 6 19 10 17 15 RAB1B 11 66033857 66034662 0.011 11 9 4 10 8 8 11 19 13 7 9 7 17 15 TMEM79 1 156251158 156251235 0.012 0 1 1 0 1 0 1 1 0 0 2 0 0 0 GGT5 22 24642529 24642530 0.012 0 1 0 1 1 0 0 2 0 1 1 0 0 0 ALKBH7 19 6369985 6370742 0.012 6 7 7 7 6 6 11 8 7 7 11 4 9 9 BAIAP2 17 79006444 79007013 0.012 11 19 12 6 7 10 17 18 17 8 14 7 16 17 AL136038.2 14 64061697 64062069 0.012 11 22 8 9 10 5 13 17 19 13 16 5 17 17 AL358176.2 1 240799808 240800561 0.012 3 12 5 8 5 9 14 15 7 10 11 5 12 12 TBX4 17 59533693 59534236 0.012 6 11 9 6 5 7 15 11 10 6 13 5 3 1 GZMM 19 543219 543909 0.012 5 10 4 5 6 6 13 7 7 6 8 5 9 9