Koos Boeve

60 Chapter 3 not seen: all patients with positive SLNs had at least one positive SLN in level I-III. Infiltrative tumour border configuration (p = 0.008) and pT2 tumour stage (p = 0.036) showed an association with lymph node status (Table 1). Oral squamous cell carcinoma Inclusion criteria - cT1-2N0 And pT1-2 - First primary head neck tumor - Surgical resection of the tumor - Neck staging by SLNB Total number: 91 pN0 66 (73%) pN+ 25 (27%) Isolated regional recurrence in the SLNB- neck: 4 (4%) Macrometastasis 11 (44%) Micrometastasis 7 (28%) Isolated tumor cells 7 (28%) Positive lymph nodes in MRND 5 (45%) Positive lymph nodes in MRND 0 (0%) 2 2 Figure 1. Flowchart of the UMCG and MCL cT1-2N0 oral squamous cell carcinoma cohort. In total 91 patients were used for analysis. A total of 25 patients had metastasis positive SLNB. Two patients with pN0 and two patients with pN+ SLNB neck status were diagnosed with isolated regional recurrence in the SLNB negative neck side. Abbreviations: pN0: All SLNs negative for metastasis. pN+: at least one SLN positive for metastasis. MRND: modified radical neck dissection. SLNB: sentinel lymph node biopsy