Xuxi Zhang

Supplementary Table S2 Risk of bias Study Sequence generation Allocation concealment Blinding Incomplete outcome data Selective reporting other Thom, D. H., 2013 [18] Low risk Low risk High risk Low risk Unclear risk Low risk Murrock, C. J., 2009 [27] Low risk Low risk High risk Low risk Unclear risk Low risk Lorig, K., 2009 [28] Low risk Unclear risk High risk Low risk Unclear risk Low risk Lujan, J., 2007 [32] Unclear risk Unclear risk High risk Low risk Unclear risk Low risk Duggan, C., 2014 [16] Unclear risk Unclear risk Unclear risk Low risk Unclear risk Low risk Cade, J. E., 2009 [30] Unclear risk Unclear risk High risk Low risk Unclear risk Low risk Gagliardino, J. J., 2013 [20] Unclear risk Unclear risk High risk Low risk Unclear risk Low risk Lorig, K., 2008 [31] Unclear risk Unclear risk High risk Low risk Unclear risk Low risk Smith, S. M., 2011 [23] Low risk Unclear risk High risk Low risk Unclear risk Low risk Philis ‐ Tsimikas, A., 2011 [24] Low risk Unclear risk High risk Low risk Unclear risk Low risk Dale, J., 2009 [29] Low risk Unclear risk High risk Low risk Unclear risk Low risk Prezio, E. A., 2013 [19] Unclear risk Unclear risk High risk Low risk Unclear risk Low risk Perez ‐ Escamilla, R., 2014 [18] Low risk Low risk High risk Low risk Unclear risk Low risk Baghianimoghadam, M. H., 2012 [22] Unclear risk Unclear risk High risk Low risk Unclear risk Low risk Rothschild, S. K., 2014 [14] Low risk Unclear risk High risk Low risk Unclear risk Low risk Ruggiero, L., 2010 [25] Unclear risk Unclear risk High risk Low risk Unclear risk Low risk Long, J. A., 2012 [21] Low risk Unclear risk High risk Low risk Unclear risk Low risk Tang, T. S., 2014 [13] Unclear risk Unclear risk Unclear risk Low risk Unclear risk Low risk Chan, J. C. N., 2014 [17] Low risk Low risk High risk Low risk Unclear risk Low risk Heisler, M., 2010 [26] Unclear risk Unclear risk Unclear risk Low risk Unclear risk Low risk 154 Chapter 6

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