Xuxi Zhang

Supplementary Table S1 Characteristics of eligible studies included in meta ‐ analysis Study Number of participants Baseline characteristics of participants Study design and Location Intervention Intervention group Control group ABCD trial, 2002 Baseline: Intervention group (IG): 237 Control group (CG): 243 Follow ‐ up (5 years): IG: 195 CG: 202 Patients with type 2 diabetes Female (%): 47 Mean age: 58.5±0.6 Duration of diabetes (year): 8.8±0.5 Glycated hemoglobin (HbA1c) (%): 11.5±0.2 Blood pressure (mm Hg): Systolic: 135.6±0.8 Diastolic: 84.4±0.2 Total Cholesterol (mg/dl): LDL:  ‐  HDL:  ‐  BMI: 31.5±0.4 Without diabetic retinopathy (%): 50 Patients with type 2 diabetes Female (%): 44 Mean age: 59.6±0.5 Duration of diabetes (year): 9.2±0.5 HbA1c (%): 11.6±0.2 Blood pressure (mm Hg): Systolic: 137.2±0.9 Diastolic: 84.4±0.2 Total Cholesterol (mg/dl): LDL:  ‐  HDL:  ‐  BMI: 31.5±0.4 Without diabetic retinopathy (%): 50 RCT USA Blood ‐ pressure ‐ control intervention Intensive (10 mmHg below the Baseline) control vs. Moderate (80 to 89mmHg) control ACCORD Eye Study, 2010 Glycemic control study Baseline and Follow ‐ up (4 years) * IG: 1429 CG: 1427 Patients with type 2 diabetes Female (%):37.6 Mean age: 61.6±6.4 Duration of diabetes (year): 9.8±7.1 HbA1c (%): 8.2±1.0 Blood pressure (mm Hg): Systolic: 134.3±16.6 Diastolic: 74.9±10.3 Total Cholesterol (mg/dl): LDL: 100.8±33.4 HDL: 42.0±11.4 BMI: 32.4±5.5 Without diabetic retinopathy (%): 51.1 Patients with type 2 diabetes Female (%): 38.7 Mean age: 61.5±6.3 Duration of diabetes (year): 10.1±7.2 HbA1c (%): 8.3±1.0 Blood pressure (mm Hg): Systolic: 134.7±17.4 Diastolic: 75.0±10.6 Total Cholesterol (mg/dl): LDL: 100.7±32.1 HDL: 41.9±111.1 BMI: 32.5±5.4 Without diabetic retinopathy (%):50.6 RCT USA and Canada Glycemic ‐ control intervention Intensive glycemic control (targeting HbA1c level of 6.0%) vs. Standard control (target of 7.0–7.9%) Blood pressure study Patients with type 2 diabetes Female (%): 47.9 Mean age: 61.3±6.1 Patients with type 2 diabetes Female (%): 45.3 Mean age: 61.5±6.6 RCT USA and Canada Blood ‐ pressure ‐ control intervention 180 Chapter 7