Xuxi Zhang

Supplementary Table S6 GRADE Evidence Profile: DR Worsening Quality assessment No of patients Effect Quality Importance No of studies Design Risk of bias Inconsistency Indirectness Imprecision Other considerations Interventions targeting modifiable risk factors of DR Control Relative (95% CI) Absolute DR Worsening (follow ‐ up 1 to 7.5 years) 7 randomised trials serious 1 no serious inconsistency no serious indirectness no serious imprecision strong association 2 149/619 (24.1%) 183/555 (33%) OR 0.62 (0.47 to 0.80) 96 fewer per 1000 (from 47 fewer to 142 fewer)  HIGH CRITICAL DR Worsening: Blood ‐ pressure ‐ control intervention (follow ‐ up 5 ‐ 7.5 years) 2 randomised trials no serious risk of bias no serious inconsistency no serious indirectness serious 3 none 72/226 (31.9%) 84/177 (47.5%) OR 0.52 (0.34 to 0.78) 155 fewer per 1000 (from 61 fewer to 240 fewer)  MODERATE IMPORTANT DR Worsening: Glycemic ‐ control intervention (follow ‐ up 1 to 6 years) 4 randomised trials very serious 1 no serious inconsistency no serious indirectness no serious imprecision none 77/381 (20.2%) 96/364 (26.4%) OR 0.71 (0.50 to 1.00) 61 fewer per 1000 (from 112 fewer to 0 more)  LOW IMPORTANT DR Worsening: Multifactorial intervention (follow ‐ up 4.3 years) 1 randomised trials no serious risk of bias no serious inconsistency no serious indirectness very serious 4 none 0/12 (0%) 3/14 (21.4%) not pooled not pooled not applicable DR Worsening: Follow ‐ up<2 years (follow ‐ up 1 to 2 years) 2 randomised trials very serious 5 no serious inconsistency no serious indirectness no serious imprecision none 18/50 (36%) 19/49 (38.8%) OR 0.91 (0.40 to 22 fewer per 1000 (from  LOW IMPORTANT 7 197 Prevention and control of diabetic retinopathy