Xuxi Zhang

ISBN: 978-94-6375-931-1 ELECTRONIC ISBN: 978-94-6416-073-4 The financial support by the Department of Public Health, Erasmus MC, Rotterdam, and the Erasmus University Rotterdam for the publication of this thesis is gratefully acknowledged. The studies presented in this thesis were financially supported by grants from the European Union, CHAFEA, third health programme, number 20131201 and the European Union’s Health Programme (2014-2020), the project / joint action ‘738202 / SEFAC’. Xuxi Zhang is supported by a China Scholarship Council (CSC) PhD Fellowship for her PhD study in Erasmus MC, Rotterdam, the Netherlands. The scholarship file number is 201706010358. Cover design, layout, and printing: Ridderprint BV | www.ridderprint.nl Copyright © 2020 by Xuxi Zhang All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise without written permission from the author or the copyright-owning journals for articles published or accepted.