Xuxi Zhang

Supplementary Table S2 Multivariate linear regression models (frequency of moderate physical activity at baseline and follow ‐ up scores of frailty) Items 12 ‐ month follow ‐ up overall frailty 12 ‐ month follow ‐ up physical frailty 12 ‐ month follow ‐ up psychological frailty 12 ‐ month follow ‐ up social frailty Crude Model B(95%CI) Adjusted Model B(95%CI) Crude Model B(95%CI) Adjusted Model B(95%CI) Crude Model B(95%CI) Adjusted Model B(95%CI) Crude Model B(95%CI) Adjusted Model B(95%CI) Baseline frequency of moderate physical activity Regular frequency Reference Reference Reference Reference Reference Reference Reference Reference Low frequency 0.39 b (0.13,0.66) 0.28 a (0.01,0.55) 0.27 b (0.08,0.45) 0.18( ‐ 0.01,0.37) 0.21 c (0.10,0.31) 0.16 b (0.05,0.27) 0.05( ‐ 0.02,0.13) 0.06( ‐ 0.02,0.13) Baseline overall frailty 0.69 c (0.65,0.73) 0.65 c (0.61,0.69) Baseline physical frailty 0.66 c (0.62,0.70) 0.62 c (0.58,0.67) Baseline psychological frailty 0.56 c (0.51,0.60) 0.54 c (0.50,0.59) Baseline social frailty 0.62 c (0.59,0.66) 0.39 c (0.34,0.44) Age 0.04 c (0.02,0.07) 0.03 b (0.01,0.04) 0.01 a (0.00,0.02) 0.01( ‐ 0.00,0.01) Sex Male Reference Reference Reference Reference Female 0.24( ‐ 0.01,0.48) 0.11( ‐ 0.06,0.29) 0.12 a (0.02,0.22) 0.04( ‐ 0.03,0.11) Country Spain Reference Reference Reference Reference Reference Reference Reference Reference Greece ‐ 0.05( ‐ 0.46,0.36) ‐ 0.20( ‐ 0.21,0.62) ‐ 0.21( ‐ 0.50,0.07) ‐ 0.08( ‐ 0.37,0.21) 0.18 a (0.02,0.35) 0.25 b (0.08,0.42) 0.08( ‐ 0.04,0.20) 0.21 b (0.09,0.33) Croatia 0.83 c (0.50,1.17) 0.96 c (0.57,1.36) 0.44 c (0.20,0.67) 0.54 c (0.26,0.81) 0.32 c (0.19,0.45) 0.35 c (0.19,0.51) 0.17 b (0.07,0.27) 0.22 b (0.10,0.33) The Netherlands ‐ 0.19( ‐ 0.55,0.18) ‐ 0.08( ‐ 0.49,0.32) ‐ 0.11( ‐ 0.37,0.14) 0.01( ‐ 0.28,0.29) ‐ 0.16 a ( ‐ 0.30, ‐ 0.01) ‐ 0.11( ‐ 0.27,0.05) 0.05( ‐ 0.06,0.16) ‐ 0.01( ‐ 0.11,0.12) The United Kingdom ‐ 0.45 b ( ‐ 0.76, ‐ 0.14) ‐ 0.45 a ( ‐ 0.84, ‐ 0.07) ‐ 0.45 c ( ‐ 0.67, ‐ 0.23) ‐ 0.43 b ( ‐ 0.70, ‐ 0.16) ‐ 0.15 a ( ‐ 0.28, ‐ 0.03) ‐ 0.10( ‐ 0.26,0.05) 0.12 a (0.02,0.21) 0.04( ‐ 0.07,0.15) Educational level Tertiary or higher Reference Reference Reference Reference Secondary or equivalent 0.12( ‐ 0.26,0.51) 0.13( ‐ 0.14,0.40) 0.04( ‐ 0.12,0.19) ‐ 0.00( ‐ 0.11,0.11) Primary or less versus 0.55 a (0.11,0.98) 0.40 a (0.10,0.71) 0.17( ‐ 0.01,0.34) 0.07( ‐ 0.06,0.19) Living situation Living with others Reference Reference Reference Reference 68 Chapter 3

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