Xuxi Zhang

Supplementary Table S2 Multivariate linear regression models (frequency of moderate physical activity at baseline and follow ‐ up scores of frailty) (Continued) Items 12 ‐ month follow ‐ up overall frailty 12 ‐ month follow ‐ up physical frailty 12 ‐ month follow ‐ up psychological frailty 12 ‐ month follow ‐ up social frailty Crude Model B(95%CI) Adjusted Model B(95%CI) Crude Model B(95%CI) Adjusted Model B(95%CI) Crude Model B(95%CI) Adjusted Model B(95%CI) Crude Model B(95%CI) Adjusted Model B(95%CI) Living alone 0.06( ‐ 0.19,0.31) ‐ 0.12( ‐ 0.29,0.06) ‐ 0.13 b ( ‐ 0.23, ‐ 0.03) 0.61 c (0.52,0.70) Smoking No Reference Reference Reference Reference Yes 0.02( ‐ 0.39,0.43) ‐ 0.15( ‐ 0.44,0.14) 0.11( ‐ 0.06,0.27) 0.07( ‐ 0.05,0.18) Alcohol risk No Reference Reference Reference Reference Yes ‐ 0.23( ‐ 0.48,0.02) ‐ 0.08( ‐ 0.26,0.10) ‐ 0.12 a ( ‐ 0.22, ‐ 0.01) ‐ 0.06( ‐ 0.13,0.02) Multi ‐ morbidity No Reference Reference Reference Reference Yes 0.59 b (0.20,0.97) 0.50 c (0.22,0.77) 0.10( ‐ 0.06,0.25) 0.07( ‐ 0.04,0.18) Intervention condition Control group Reference Reference Reference Reference Intervention group ‐ 0.50 c ( ‐ 0.72, ‐ 0.28) ‐ 0.42 c ( ‐ 0.58, ‐ 0.27) ‐ 0.05( ‐ 0.14,0.04) ‐ 0.02( ‐ 0.08,0.05) Adjusted R 2 , % 53.7 55.2 49.0 50.8 36.7 37.5 41.4 48.2 a p <.05, b p <.01, c p <.001, significant effect estimates in bold 3 69 Longitudinal association between physical activity and frailty

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