Maarten Cozijnsen

118 Table 1. Overview of prospective studies that compared the efficacy of combination therapy to anti- TNF monotherapy in pediatric and adult CD patients Type Year Authors Patients N Treatment Duration RCT 2014 Kierkus et al(15) Pediatric CD, week 10 responders to IFX 84 [1] IFX+IM [2] IFX 54 wks Post- analysis of RCT 2014 Hyams et al (16) and Eckert et al (17) Pediatric CD, week 4 responders to ADA 188 [1] ADA+IM [2] ADA 52 wks RCT 2014 Feagan et al (COMMIT)(13) Adult CD, receiving prednisone<6wk 126 [1] IFX+MTX [2] IFX+PCB 50 wks RCT 2010 Colombel et al (SONIC)(11) Adult CD, moderate- to-severe disease 508 [1] IFX+AZA [2] IFX+PCB; [3] AZA+PCB 26 wks RCT 2008 Van Assche et al(14) Adult CD, controlled disease 80 [1] IFX+AZA [2] IFX 104 wks Post-hoc analysis of 11 RCTs* 2013 Jones et al (27) Adult CD [1] Anti-TNF+IM [1a] IFX+IM [1b] ADA+IM [1c] CZP+IM [2] Anti-TNF [2a] IFX [2b] ADA [2c] CZP Post-hoc analysis of 18 RCTs* 2014 Kopylov et al (26) Adult CD ADA ADA+IM