Maarten Cozijnsen

General discussion The primary aim of this thesis was to compare the efficacy and safety of top-down and step-up infliximab treatment strategies within pediatric IBD. Additional aims were to develop a novel index that correlates with mucosal inflammation, to study differences in the immune responses upon infliximab or prednisolone treatment, to evaluate the real-world efficacy of adalimumab and to compare the benefits and risks of combining anti-TNF and immunomodulator therapy with anti-TNF monotherapy. In this chapter the results of this thesis are put into perspective and recommendations for further research are given.