Maarten Cozijnsen

42 Table 2. The Mucosal-Inflammation Non-Invasively (MINI) index Item Points 1. Stool 0-1 Normal or liquid stools, no blood ≤ 2 Semi-formed with small blood, or 2-5 liquid Gross bleeding, or ≥ 6 liquid, or nocturnal diarrhea 0 4 8 2. Fecal calprotectin (μg/g) <50 50-99.9 100-299.9 300-599.9 600-899.9 ≥900 -3 0 5 7 9 12 3. ESR (mm/hr) and CRP (mg/L) ESR<10 and CRP<5 30>ESR≥10 or 10>CRP≥5 50>ESR≥30 or 30>CRP≥10 ESR≥50 or CRP≥30 0 1 2 5 Sum of MINI -3 to 25 User guide: While it is possible to score the MINI index with either CRP or ESR, both are preferred. Score the highest of CRP or ESR. The stool item: The intent is to score the stool pattern during the preceding week. First categorize the subject as having blood in the stool or not. If there is no blood in the stool, score as follows: Formed stools or up to 1 loose stool daily = 0; 2-5 liquid or very loose stools on 1 or more days = 4; 6 or more liquid or very loose stools on 1 or more days or any nocturnal diarrhea = 8. If blood is present in the stool, score as follows: Small amounts of blood (on toilet paper or small spots in stool) = 4; Any gross bleeding (large amounts on stool or colors the water in the toilet) = 8. -5 0 5 10 15 20 25 30 0 10 20 30 40 MINI index SESCD Derivation cohort Validation cohorts MH Cutoff AUROC (95%CI) Sens/spec PPV/NPV > 11 0.87 (0.84-0.91) 91%/68% 67%/91% 8-11 - - < 8 0.92 (0.89-0.96) 85%/86% 68%/94% N=24 N=61 N=55 N=46 N=75 N=61 Figure 2. The MINI index stratified by severity of endoscopic inflammation, as measured by the SESCD in the derivation and validation cohorts