Maarten Cozijnsen

78 Infliximab + azathioprine Prednisolone + azathioprine Increased 0% 0% Decreased 37% 0% Unchanged 63% 100% CASP-8, CCL23, CCL4, CD244, CD40, CD5, CDCP1, CXCL1, CXCL10, CXCL11, CXCL5, CXCL9, EN-RAGE, HGF, IFN-γ, IL-12B, IL-18, IL-18R1, IL-6, IL-7, IL-8, LAP TGF-beta-1, LIF-R, MCP-3, MIP-1 alpha, MMP-1, OPG, OSM, PD-L1, SLAMF1, TGF-alpha, TNFSF14, TWEAK, VEGF-A 4E-BP1, ADA, ARTN, AXIN1, Beta-NGF, CCL11, CCL19, CCL20, CCL25, CCL28, CD6, CSF-1, CST5, CX3CL1, CXCL6, DNER, FGF-19, FGF-21, FGF-23, FGF-5, Flt3L, hGDNF, IL-1α, IL-10, IL-10RA, IL-10RB, IL-13, I L15-RA, IL-17A, IL-17C, IL-2, I L-20, IL-20 RA, IL-22 RA1, IL-24, IL-2RB, IL-33, IL-4, IL-5, LIF, MCP-1, MCP-2, MCP-4, MMP-10, NRTN, NT-3, SCF, SIRT2, ST1A1, STAMPB, TNF, TNFB, TNFRSF9, TRAIL, TRANCE, TSLP, uPA B. Leukocyte counts Leukocyte count TD baseline TD wk 10 SU baseline SU wk 10 0 5 10 15 20 * ns x10^9/L Lymphocyte count TD baseline TD wk 10 SU baseline SU wk 10 0 1 2 3 4 * ns x10^9/L Monocyte count TD baseline TD wk 10 SU baseline SU wk 10 0.0 0.5 1.0 1.5 2.0 * ns x10^9/L Neutrophil count TD baseline TD wk 10 SU baseline SU wk 10 0 5 10 15 * ns x10^9/L C. Whole blood RNA expression TD Baseline SU Baseline TD wk 10 SU wk 10 TD wk 52 SU wk 52 0 10 30 TD SU PCDAI Clinical disease activity (PCDAI) TDbaseline TDwk 10 SUbaseline SUwk 10 0 20 40 60 80 * * 10 30 A. Clinical disease activity Faecal calprotectin TD baseline TD wk 10 SU baseline SU wk 10 0 500 1000 1500 2000 * ns 100 microg/g Endoscopic disease activity (SES-CD) TD baseline TD wk 10 SU baseline SU wk 10 0 10 20 30 40 * ns 5 D. Serum inflammatory proteins Infliximab + azathioprine Prednisolone + azathioprine TD Baseline SU Baseline TD wk 10 SU wk 10 TD wk 52 SU wk 52 0 1 30 TD SU PCDAI Infliximab + azathioprine Prednisolone + azathioprine Week 0 Week 10 Week 0 Week 10