Maarten Cozijnsen

99 Chapter 5 Adalimumab therapy in children with infliximab-refractory CD these patients stopped when surgery was performed, even when adalimumab therapy continued after. Patients requiring perianal surgery or surgery for reasons other than disease progression were not categorized as having failed adalimumab and follow-up in these patients therefore continued. Statistical analysis Data collection and analysis were performed using SPSS version 21. Continuous nonparametric data are presented as median (IQR), parametric data was absent. Categorical data are presented by the number of cases and the proportion of cases (%). Kaplan- Meier analyses and Cox proportional hazard models were used to analyze and visualize adalimumab failure in relation to time. The Fisher exact test was used to compare categorical data between groups. We used 0.05 as the cut-off point for statistical significance. Ethical considerations This study was exempted from Institutional Review Board approval as it involved the collection of data generated by routine medical care. The data were collected and recorded by the investigators in such a manner that subjects could not be identified, directly or through identifiers linked to the subjects.