Marjon Borgert

150 Chapter 6 τ = − 0.08 0 10 20 30 40 50 60 70 80 90 100 Per 2 weeks Per month Per quarter Per 6 months Per year More than 1 year time frame compliance measurement Level of compliance in % Overall τ = − 0.183 0 10 20 30 40 50 60 70 80 90 100 Per 2 weeks Per month Per quarter Per 6 months Per year More than 1 year time frame compliance measurement Level of compliance in % Central line bundle τ = 0.372 0 10 20 30 40 50 60 70 80 90 100 Per 2 weeks Per month Per quarter Per 6 months Per year More than 1 year time frame compliance measurement Level of compliance in % Ventilator bundle τ = − 0.224 0 10 20 30 40 50 60 70 80 90 100 Per 2 weeks Per month Per quarter Per 6 months Per year More than 1 year time frame compliance measurement Level of compliance in % Sepsis bundle Time frame: Pre/post design & compliance calculated by AON−approach Figure S3. Relation between compliance and time frame in which compliance is measured Overall, there is no relation between the time frame and compliance (τ = -0.080, p = 0.639), neither for each bundle separately: central line bundle: τ = -0.183, p = 0.643; ventilator bundle: τ = 0.372, p = 0.162; sepsis bundle: τ = -0.224, p = 0.602).