Peter van Mourik

17 General Introduction 31. Neuberger, T., Burton, B., Clark, H. & Van Goor, F. Use of Primary Cultures of Human Bronchial Epithelial Cells Isolated from Cystic Fibrosis Patients for the Pre-clinical Testing of CFTR Modulators. in 39–54 (2011). doi:10.1007/978-1- 61779-117-8_4 32. Brewington, J. J. et al. Brushed nasal epithelial cells are a surrogate for bronchial epithelial CFTR studies. JCI Insight 3, (2018). 33. Pranke, I. M. et al. Correction of CFTR function in nasal epithelial cells from cystic fibrosis patients predicts improvement of respiratory function by CFTR modulators. Sci. Rep. 7, 7375 (2017). 34. Ramsey, B. W. et al. A CFTR Potentiator in Patients with Cystic Fibrosis and the G551D Mutation. N. Engl. J. Med. 365, 1663–1672 (2011). 35. De Boeck, K. et al. CFTR biomarkers: Time for promotion to surrogate end- point? Eur. Respir. J. 41, 203–216 (2013). 1