Peter van Mourik

218 Appendices LIST OF ABBREVIATIONS Ad-DF+++ - Advanced Dulbecco’s Modified Eagles Medium with Nutrient Mixture F-12 Hams (Ad-DF) 500ml +1 % glutamax/1 % hepes buffer/1 % pen-strep) AON - Antisense oligonucleotides ATP - Adenosinetriphosphate AUC - Area under the curve BMI - Body mass index cAMP - Cyclic adenosine monophosphate CF - Cystic Fibrosis CFTR - Cystic Fibrosis Transmembrane Conductance Regulator CM - Colon organoid medium DMEM - Dulbecco’s Modified Eagles Medium DMSO - Dimethyl sulfoxide ECFS-CTN - European Cystic Fibrosis Society – Clinical Trial Network EDTA - Ethylenediaminetetraacetic acid ELOXX - Eloxx Pharmaceuticals EMA - European Medicines Agency FBS - Fetal bovine serum FDL - Flatley Discovery Labs FDA - Food and Drug Administration FIS - Forskolin induced swelling FRT - Fisher rat thyroid g - Gravity (units) GCPR - G-protein coupled receptor HBE - Human bronchial epithelial hEGF - Human epithelial growth factor HIT-CF - Human Individualized Treatment for CF HNE - Human nasal epithelial HUB - Hubrecht Organoid Technology HSP90 - Endogenous heat shock protein 90 ICM - Intestinal Current Measurement IRB - Institutional Review Board IQR - Interquartile range