Peter van Mourik

36 Chapter 2 Supplementary figure 1. Continued.CFTR protein expression and organoid swelling in the presence of 3 µM VX-770 and 0.128 µM forskolin, (G) normalized CFTR protein expression and vehicle-corrected organoid swelling in the presence of 3 µM VX-770 and 0.05 µM forskolin stimulation, (H) normalized CFTR mRNA expression and vehicle-corrected organoid swelling in the presence of 3 µM VX-770 and 0.128 µM forskolin stimulation, (I) normalized CFTR protein expression and vehicle-corrected organoid swelling in the presence of 3 µM VX-770 and 0.128 µM forskolin stimulation, (J) Sweat chloride concentration and normalized R117H-CFTR mRNA expression, (K) Sweat chloride concentration and organoid swelling after stimulation with 0.128 µM forskolin, (L) Sweat chloride concentration and organoid swelling after stimulation with 0.05 µM forskolin and (M) Sweat chloride concentration and CFTR protein expression.