Peter van Mourik

63 Potentiator synergy in rectal organoids Supplementary figure S2. Incubation of VX-770, genistein and curcumin in rectal organoids derived from a CF subject expressing two class I CFTR mutations. Forskolin-induced swelling (FIS) of organoids stimulated with near-saturating concentrations of VX-770, genistein (gen), curcumin (cur) or combinations at a saturating concentration of forskolin, corrected for the FIS without addition of a potentiator. The subject was measured at 2 independent culture time points in duplicate. Mean ± SD. 3