Fehmi Keçe

Coagulation Markers and Micro-Embolic Signals 119 5 5.3 Results The average temperature with the PVAC-Gold catheter in 997 applications was 52±3 °C. The PVAC-Gold catheter induced a pro-coagulant state which was characterized by significant changes in the coagulation markers (p=0.001 for all markers). The mentioned changes in the different coagulation markers were 17% for prothrombin fragment (1337 to 1111 ng/L), 17% for fibrinogen (3.5 to 2.9 g/L), 45% for von Willebrand factor antigen (1.1 to 1.6 kIU/mL), 23% for D-Dimer (266 to 327 µg/L), 16% for soluble p-selectin (81 to 68 µg/L), and 17% for tissue plasminogen activator (3.6 to 3.0 µg/L). Early changes in fibrinogen (b=0.429, p=0.014) and von Willebrand factor (b=0.418, p=0.022) and late changes in D-dimer (b=0.387, p=0.038) were related with MES counts. Other early and late changes in coagulation markers were not related with MES.