Fehmi Keçe

Optimizing Ablation Duration using Dormant Conduction 131 6 6.3 Results 6.3.1 Baseline characteristics Table 1 shows the baseline clinical characteristics of the 75 randomized patients. There were no significant differences in age, gender and co-morbidities between the 90, 120 and 150s groups. All patients had a normal ejection fraction and the mean left atrial diameter was 40±5mm. Table 1. Baseline characteristics. 90s (n=25) 120s(n=25) 150s (n=25) P value Age (years) 61±11 59±11 60±11 0.857 Male gender 15 (60) 15 (60) 18 (72) 0.594 AF duration (months) 51 [37-112] 24 [12-54] 41 [18-69] 0.066 CHA 2 DS 2 -VASc score 1.6±1.4 1.1±1.0 1.4±1.1 0.380 LA diameter (mm) 39±6 38±5 40±5 0.542 Body Mass Index (kg/m²) 25.5±3.5 25.0±3.9 25.7±3.4 0.847 AAD at baseline 21 (84) 19 (76) 20 (80) 0.329 Hypertension 11 (44) 7 (28) 14 (56) 0.133 Dyslipidemia 12 (48) 5 (20) 8 (32) 0.109 Diabetes 1 (4) 1 (4) 1 (4) 1.000 Coronary Artery Disease 1 (4) 2 (8) 1 (4) 0.768 Structural Heart Disease 4 (16) 4 (16) 1 (4) 0.372 Values are reported as the mean±standard deviation, median (interquartile range), or n (%). 6.3.2 Procedural details The mean procedure time and mean ablation duration for all groups were respectively 126±31 minutes and 17±5 minutes and no significant differences were seen between the three groups (p=0.053 and p=0.132, respectively, Table 2). The mean cryo-application duration was significantly different among the groups (146±28s, 167±30s and 192±34s respectively, p<0.001). The mean number of cryo-applications per patient was 6±2 (p=0.339). Time-to-isolation could be determined for 262 veins (88%). In the remaining veins the disappearance of PV potentials were unclear. Analyses on the differences in biophysical data of the cryoballoon, on the incidence of reconnection and DC and on the predictors of reconnection/DC with exclusion of these pulmonary veins did not influence the results (online supplement). There were no significant differences in time- to-isolation between the four pulmonary veins. In addition, there were no differences in