Fehmi Keçe

Chapter 2 42 Table 2. Overview of literature on ablation with the cryoballoon. Author, year (study type) Number of patients, ablation device and protocol* PAF (%) Preventive techniques AAD free survival (1 year) (%) Procedural, ablation time and fluoroscopy time (min) Complications (%) Aryana, 2014 (79) (retrospective) N=140; CB 3x5 86 Temperature balloon (-60) Phrenic nerve pacing(20mA, 1500ms) 78 DC testing 209 (p<0.001) 61 (p<0.001) 42 (p<0.001) - Transient PNP 12.1 and permanent PNP 0.7 - Vascular access 0.7 - Other: myocardial infarction 0.7 (after 8 weeks) Aryana, 2014 (79) (retrospective) N=200; CBA 2x3-4 72 Temperature balloon (-60) Phrenic nerve pacing(20mA, 1500ms) 83 DC testing 154 (p<0.001) 47 (p<0.001) 27 (p<0.001) - Pericardial effusion/Cardiac tamponade 1.5 - Transient PNP 16 and permanent PNP 0.5 - Gastroparesis 0.5 (symptoms resolved after 2 months) - Vascular access 0.5 and haemorrhage requiring blood transfusion 0.5 Other: myocardial infarction 0.5 Aryana, 2015 (82) (retrospective) N=773; CBA 1-3 x 2-4 77 Temperature balloon (-65) Phrenic nerve pacing (20-25mA, 800-1500ms) 77 (P<0.001) 145 (p<0.001) 40 (p<0.001) 29 (p<0.001) - Pericardial effusion/Cardiac tamponade 0.6 - Transient ST-elevation 0.1 - Transient PNP 7.6 and permanent PNP 1.2 - Gastropareseis 0.1 - Vascular access 0.3 and venous thromboembolism 0.3 Aytemir, 2013 (83) (observational) N=236; CBA 2x5 80 Phrenic nerve pacing 81 (18 months IQR 6-27) 72 Median 2 (IQR 2-5) 14 - Cardiac tamponade 0.8 - Transient PNP 1.2 - Vascular access 3.8 Chun, 2017 (122)(registry) N=589 CB(A); N=286 Laserballoon CB 2x5; CBA 2x4 100 Oesophageal temperature monitoring N.A. 106 (p=0.004) N.A. 13 (p<0.001) - Cardiac tamponade 0.1 (p=0.024) - Stroke/TIA 0.4 - Permanent PNP 1.7 (p=0.001) - Vascular access 2.9 - Other: hemothorax 0.2