Ellen de Kort

116 Chapter 7 Table 2. Patient characteristics and outcomes in 3 starting doses Dosing groups 1.0 mg/kg n = 30 1.5 mg/kg n = 23 Patient characteristics Gestational age (wk), median (IQR) 27.5 (25.86-30.93) 26.86 (25.57-30.14) Birth weight (gr), median (IQR) 1,075 (784-1,410) 908 (780-1,600) Postnatal age (hr), median (IQR) 156 (12-397) 37.35 (21-387) Male gender, n (%) 22 (73) 12 (52) Propofol dosing Extra propofol administered, n (%) 25 (83) 20 (87) Cumulative propofol dose (mg/kg), median (IQR) 3.0 (1.9-4.0) 3.4 (2.5-4.5) Primary outcome No. of patients with data available 30 (100) * 23 (100)† Effective sedation without side-effects, n (%) 1 (3) 2 (9) Sedative effect of propofol Adequate pre-intubation sedation level, n (%) 7 (23) 7 (30) Quality of intubation No. of patients with data available 3 (10) 7 (30) Good quality of intubation 1 (33) 3 (43) Effective sedation No. of patients with data available 28 (93) 23 (100) Effective sedation, n (%) 1 (4) 3 (13) Hypotension No. of patients with data available 24 (80) 21 (91) Occurrence of hypotension, n (%) 15 (63) 11 (52) Volume resuscitation, n (% of hypotensive patients) 7 (47) 4 (36) * Both patients with missing data on effective sedation had side effects and all six patients with missing data on side effects had insufficient sedation. Therefore, a conclusion on the primary outcome could be drawn for all 30 patients. † Both patients with missing data on side effects had inadequate sedation and, therefore, a conclusion on the primary outcome could be drawn on all 23 patients. ‡ In four patients with missing data on effective sedation, side effects were present and in only one patient both data on effective sedation and side effects were missing. Therefore, a conclusion on the primary outcome could be drawn in 25 out of 26 patients.