Ellen de Kort

118 Chapter 7 Group 3 (GA 26-29 weeks, PNA <10 days) 0 5 10 15 20 25 0.0 0.5 1.0 1.5 2.0 2.5   Ineffective sedation, hypotension Ineffective sedation, normal blood pressure Effective sedation, hypotension Effective sedation, normaal blood pressure Patient, sequential Propofol starting dose (mg/ kg) Group 5 (GA 30-36 weeks, PNA <10 days) 0 5 10 15 20 25 0.0 0.5 1.0 1.5 2.0 2.5 Ineffective sedation, hypotension Ineffective sedation, normal blood pressure Effective sedation, hypotension Effective sedation, normaal blood pressure         Patient, sequential Propofol starting dose (mg/ kg) Figure 2. Dose-finding in groups 3 and 5 *Missing data on blood pressure, in the dose-finding approach considered to be normal in the absence of evidence of hypotension; # Missing data on intubation score, effective sedation only judged by pre-intubation sedation level. In group 5, the 1.0 and 1.5 mg/kg dosing subgroups both contain 6 instead of 5 patients. This was due to initial uncertainty of the suitability of the data for the primary outcome in 1 patient in both subgroups. An extra patient in both groups was included to ensure a total of 5 patient with viable data on the primary outcome. After re-evaluation, the data of all 6 patients in both subgroups turned out to be suitable.