Ellen de Kort

132 Chapter 8 Table 1. Patient characteristics and sedative effect in 3 different propofol starting doses (see original report 14 for details) Dosing groups 1.0 mg/kg n = 30 Gestational age (wk), median (IQR) 27.5 (25.86-30.93) Birthweight (g), median (IQR) 1,075 (784-1,410) Postnatal age (h), median (IQR) 156 (12-397) Male gender, n (%) 22 (73) Reason for intubation, n (%) RDS 12 (40) Apnea 6 (20) Sepsis/NEC 4 (13.3) Respiratory insufficiency 7 (23.3) Elective 1 (3.3) Other 0 Effective sedation, n (%) 1/28 (4) Extra propofol administered, n (%) 25 (83) Cumulative propofol dose (mg/kg), median (IQR) 3.0 (1.9-4.0) Abbreviations: IQR, interquartile range; NEC, necrotising enterocolitis; RDS, respiratory distress syndrome. Primary outcome measure Occurrence of hypotension and lowest MBP in three dosing groups InTable 2 data onMPB before administration of propofol, the definition of hypotension, and data on MBP after start of propofol in the three dosing groups are presented. These data show that the incidence of hypotension was not significantly different between the three groups. In the 2.0 mg/kg group more patients were treated with volume resuscitation (75%) compared to the 1.0 mg/kg (47%) and 1.5 mg/kg (36%) groups, but this difference did not reach statistical significance. The maximum decrease in MBP as percentage from baseline was equal in all three groups. However, this maximum decrease was reached significantly earlier in the 1.0 mg/kg group (18.2 minutes) compared to the 2.0 mg/kg group (28.6 minutes; p = 0.03).