Ellen de Kort

133 Blood pressure after propofol in neonates 8 Dosing groups Comparison between groups (p-values) 1.5 mg/kg n = 23 2.0 mg/kg n = 26 1.0 vs 1.5 1.0 vs 2.0 1.5 vs 2.0 26.86 (25.57-30.14) 29.07 (26.43-31.71) 0.37 0.66 0.20 908 (780-1,600) 1,215 (895-1,568) 0.46 0.51 0.19 37.35 (21-387) 19.58 (8-43) 0.68 0.01 0.04 12 (52) 18 (69) 0.16 0.77 0.25 0.53 0.27 0.35 8 (34.8) 17 (65.4) 8 (34.8) 4 (15.4) 3 (13) 2 (7.7) 2 (8.7) 2 (7.7) 1 (4.3) 0 1 (4.3) 1 (3.8) 3/23 (13) 18/24 (86) 0.21 <0.001 <0.001 20 (87) 11 (42) 1.0 0.002 0.002 3.4 (2.5-4.5) 2.0 (2.0-3.0) 0.06 0.97 0.03 Absolute changes in MBP after propofol in the 3 dosing groups The absolute changes in blood pressure compared to baseline at different time intervals after the start of propofol infusion for the three dosing groups are presented in Figure 1. These data show that MBP declined in all three groups compared to baseline, and that this decline was highest in the 2.0 mg/kg dosing group. In the 1.0 mg/kg group the decline in MBP from baseline was significant at 20, 25, 35 and 45 minutes after start of propofol administration. In the 1.5 mg/kg group the decline from baseline was significant at time points 5 up to and including 30 minutes and 55 minutes after start of propofol. Finally, in the 2.0 mg/kg group the decline in baseline was significant at all time points with the exception of 5 minutes after the start of propofol. Correcting for volume resuscitation and the administration of extra doses of propofol did not alter the results from the initial analysis (Figure 2).