Ellen de Kort

134 Chapter 8 Table 2. Blood pressure data in 3 different dosing groups Dosing groups 1.0 mg/kg n = 30 Baseline MBP (mmHg), mean (SD) 40 (11.2) Hypotension before propofol, n (%) 4/29 (14) Hypotension at any time point after start of propofol, n (%) 15/24 (63) Treatment of hypotension with volume resuscitation, n (%) 7/15 (47) Lowest MBP (mmHg) after start of propofol, mean (SD) 28 (9.5) Time after start of propfol (min) of lowest MBP, mean (SD) 18.2 (12.5) Maximum decrease in MBP as % from baseline, mean (SD) -30 (16.5) Abbreviations: MBP, mean blood pressure; SD, standard deviation. a.Systolic BP 0 5 10 15 20 25 30 35 40 45 50 55 60 -15 -10 -5 0 5 10 1.0 mg/ kg 1.5 mg/ kg 2.0 mg/ kg Time after start propofol (min) Change in systolic BP (mmHg) b.Diastolic BP 0 5 10 15 20 25 30 35 40 45 50 55 60 -15 -10 -5 0 5 10 1.0 mg/ kg 1.5 mg/ kg 2.0 mg/ kg Time after start propofol (min) Change in diastolic BP (mmHg) c.Mean BP 0 5 10 15 20 25 30 35 40 45 50 55 60 -15 -10 -5 0 5 10 1.0 mg/ kg 1.5 mg/ kg 2.0 mg/ kg Time after start propofol (min) Change in mean BP (mmHg) Figure 1. Changes of systolic, diastolic and mean blood pressure after start of propofol in 3 dosing groups