Ellen de Kort

135 Blood pressure after propofol in neonates 8 Comparison between groups (p-values) 1.5 mg/kg n = 23 2.0 mg/kg n = 26 1.0 vs 1.5 1.0 vs 2.0 1.5 vs 2.0 43 (9.7) 42 (12.3) 0.22 0.73 0.30 0/21 3 (12) 0.13 1.0 0.24 11/21 (52) 16/26 (62) 0.56 1.0 0.57 4/11 (36) 12/16 (75) 0.70 0.15 0.06 28 (6.9) 27 (5.5) 0.85 0.73 0.88 22.4 (14.3) 28.6 (18.2) 0.24 0.04 0.25 -36.4 (14.0) -32.6 (18.7) 0.07 0.15 0.73 Table 3. Analysis of blood pressure in relation to hemodynamic stability Group 1 n = 53 Group 2 n = 7 Group 3 n = 9 P -value Propofol starting dose, n (%) 1.0 mg/kg 1.5 mg/kg 2.0 mg/kg 16 (30.2) 16 (30.2) 21 (39.6) 4 (57.1) 0 3 (42.9) 4 (44.4) 3 (33.3) 2 (22.2) Baseline MBP (mmHg), mean (SD) 44.5 (10.2) 25.3 (3.1) 42.7 (10.5) <0.001 Absolute difference between baseline MBP and MBP indicating hypotension (mmHg), mean (SD) 15.0 (9.8) -4.1 (4.0) 14.9 (9.8) <0.001 Relative difference between baseline MBP and MBP indicating hypotension (%), mean (SD) 54 (35.9) -13.6 (12.4) 53 (34.2) <0.001 Hypotension at any time point after propofol administration, n (%) 28 (52.8) 7 (100) 6 (66.7) 0.05 Treatment of hypotension with volume resuscitation, n (%) 10/28 (36) 3/7 (43) 2/6 (33) 0.28 Lowest MBP (mmHg) after start of propofol, mean (SD) 28.5 (7.2) 20.9 (4.3) 27 (7.8) 0.01 Time after start of propofol (min) of lowest MBP, mean (SD) 23.5 (16.2) 19.9 (12.5) 24.8 (17.7) 0.88 Maximum decrease in MBP as % from baseline, mean (SD) -34.3 (16.6) -16.9 (16.1) -35.9 (11.7) 0.05 Group 1 = hemodynamically stable (no baseline hypotension and no sepsis/NEC); group 2 = baseline hypotension; group 3 = high risk of hemodynamic failure based on sepsis or NEC as underlying morbidity. Abbreviations: MBP, mean blood pressure; NEC, necrotizing enterocolitis; SD, standard deviation.