Ellen de Kort

141 Blood pressure after propofol in neonates 8 CONCLUSION Propofol used as premedication to sedate neonates for endotracheal intubation causes a profound and prolonged decrease in MBP which is more pronounced with a higher starting dose. It also causes a high incidence of propofol-induced hypotension, irrespective of the starting dose that is used. Although premedication for endotracheal intubation is essential, propofol might not be the preferred drug. When propofol is used in neonates, starting with a low dose and titrating according to sedative effect seems the safest strategy with the least pronounced effect on blood pressure.