Ellen de Kort

The research presented in this thesis was performed at the Department of Pediatrics, Máxima MC, Veldhoven, the Netherlands and the Department of Pediatrics, Erasmus MC Sophia Children’s Hospital, Rotterdam, the Netherlands. The research presented in this thesis was financially supported by Fonds Nuts Ohra, the Netherlands (grant number 1201-020). The design and printing of this thesis was financially supported by Erasmus University Rotterdam, Chipsoft, Chiesi Pharmaceuticals and Fresenius Kabi. Cover design and layout: © evelienjagtman.com Print: Ridderprint, www.ridderprint.nl ISBN: 978-94-6416-037-6 Copyright © 2020 Ellen de Kort, ‘s-Hertogenbosch, the Netherlands. All rights reserved. No parts of this thesis may be reproduced or transmitted in any form or by any means without prior permission of the author.