Ellen de Kort

CONTENTS Chapter 1 General introduction and outline of the thesis 7 Premedication use during INSURE and LISA Chapter 2 Sedation of newborn infants for the INSURE procedure, are we sure? 21 Chapter 3 Insufficient sedation and severe side effects after fast administration of remifentanil during INSURE in preterm newborns. 41 Chapter 4 Quality assessment and response to less invasive surfactant administration (LISA) without sedation. 51 Assessment of premedication effect Chapter 5 Assessment of sedation level prior to neonatal intubation: a systematic review. 71 Chapter 6 Evaluation of an Intubation Readiness Score to assess neonatal sedation before intubation. 91 Propofol as premedication for neonatal intubation Chapter 7 Propofol for endotracheal intubation in neonates: a dose- finding trial. 107 Chapter 8 Propofol in neonates causes a dose-dependent profound and protracted decrease in blood pressure. 127 Summary, conclusions and perspectives Chapter 9 General discussion and future perspectives 147 Chapter 10 Summary 173 Chapter 11 Nederlandse samenvatting 181 Appendices Author affiliations List of publications PhD Portfolio About the author Dankwoord 193 197 201 207 209