Ellen de Kort

59 Less Invasive Surfactant Administration without sedation 4 Table 2b. Patient characteristics and performer experience in relation to quality assessment Good quality n = 45 Inadequate quality n = 31 p-value Patient characteristics Gestational age (week), median (IQR) 28.3 (26.6-29.6) 28.1 (27.0-30.0) 0.70 Birth weight (g), median (IQR) 1,050 (788-1,313) 1,000 (800-1,300) 0.76 Birth weight < 10 th percentile, n (%) 12 (27) 12 (39) 0.32 Postnatal age (h), median (IQR) 3.5 (2.5-9.6) 3.2 (2.0-10.7) 0.53 Male gender, n (%) 24 (53) 21 (68) 0.24 Procedure characteristics First attempt by neonatologist, n (%) 29 (64) 16 (52) 0.34 Success of first attempt, n (%) 34 (76) 11 (35) 0.001 In only two patients (5%) there was a brief period of bradycardia <100/min in the first 10 min after start of the LISA procedure. In both patients, heart rate restored within 1 min and never dropped below 80/min. Desaturations were more frequent: in 20 patients (54%) oxygen saturation dropped below 80% on one or more occasions in the first 10 min after start of LISA. Figure 3 shows heart rate and oxygen saturation in relation to the success rate of the first attempt and technical quality of each LISA procedure. Heart rate and oxygen saturation did not differ significantly between patients with success versus failure of the first attempt and between good versus inadequate technical quality. Therewas, however, a significant difference in the time until the deepest drop in oxygen saturation between patients with good versus inadequate technical quality. In patients with good technical quality the lowest oxygen saturation occurred after a median of 2 min after start of LISA versus a median of 5.5 min for patients in whom the technical qualitywas inadequate (p = 0.018). In patients in whom the first attempt was successful, the deepest drop in oxygen saturation occurred at a median of 4 min, and in patients inwhom the first attempt failed the deepest drop in oxygen saturation occurred at median of 2 min. This difference, however, is not statistically significant (p = 0.136). Oxygen desaturations below 80% occurred in 13/19 patients (68%) with good quality conditions and in 7/15 patients (47%) with inacceptable quality (p = 0.30). In procedures with a successful first attempt (n = 19), desaturations below 80% occurred in 13 patients (68%), while in procedures in which the first attempt failed (n = 18) these desaturations occurred in 7 patients (39%). This difference was also not statistically significant (p = 0.10).