Cindy Boer

108 | Chapter 2.2 Funding The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (Zon- Mw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Educa- tion, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. The Rotterdam Study GWAS datasets are supported by the Netherlands Organisation of Scientific Research NWO Investments (nr. 175.010.2005.011, 911-03-012), the Genetic Laboratory of the De- partment of Internal Medicine, Erasmus MC, the Research Institute for Diseases in the Elderly (014-93-015; RIDE2), the Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) Netherlands Consortium for Healthy Aging (NCHA), project nr. 050-060-810. The Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health and Boston University School of Medicine was supported by the National Institutes of Health (contract no. HHSN268201500001I, N01-HC-25195, AG18393, AR47785) and its contract with Affy- metrix, Inc. for genotyping services (N02‐HL‐6‐4278). Analyses reflect intellectual in- put and resource development from the Framingham Heart Study investigators partici- pating in the SNP Health Association Resource (SHARe) project. MSY was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Institute on Aging (NIA) (R01AR075356). Rice, Cheung and Loughlin were supported by Versus Arthritis (grant 20771), by the Medical Research Council and Ar- thritis Research UK as part of the MRC-Arthritis Research UK Centre for Integrated Re- search into Musculoskeletal Ageing (CIMA, grant references JXR 10641, MR/P020941/1 and MR/R502182/1), and by the European Union’s Seventh Framework Program for research, technological development and demonstration under grant agreement num- ber No. 305815 (D-BOARD). The research leading to the RAAK biobank and the current results has received funding from the Dutch Arthritis Association (DAA 2010_017) and the European Union’s Seventh Framework Programme (FP7/2007-2011) under grant agreement no. 259679. ATAC-seq datasets generated by MY and TDC were funded by a Harvard University Dean’s Competitive Award. Author Contributions CGB designed the study, performed the analyses, made the figures and tables, and wrote the manuscript. MSY performed the replication analysis. SJR, RCdA, KC and LS performed functional analysis and look-ups(EQTL, meQTL and differential expression), MY and TDC performed ATAC-seq analysis, US provided GWAS data of deCODE and UK-